a. Faculty of Chemistry, University of Latvia, Kr. Valdemara 48, Riga 1013, Latvia

In the title compound, alternatively called xylazine hydro-chloride monohydrate, C12H17N2S+·Cl-·H2O, the six-membered thia-zine ring is in a half-chair conformation. In the crystal structure, six component centrosymmetric clusters are formed via inter-molecular O - H⋯Cl, N - H⋯O and N - H⋯Cl hydrogen bonds involving xylazine cations, chloride anions and water mol-ecules.

a. Faculty of Chemistry, University of Latvia, Kr. Valdemara 48, Riga 1013, Latvia

b. Latvia Institute of Organic Synthesis, Aizkraukles 21, Riga 1006, Latvia

The anion of the title compound, also called sygethin dihydrate, 2K +·C18H20O6S2 2-·2H2O, has crystallographic inversion symmetry. The K+ cation is surrounded by eight O atoms in a distorted cubic coordination geometry, forming extended K - O - S networks. There are also O - H...O hydrogen bonds.

a. Faculty of Chemistry, University of Latvia, Kr. Valdemara 48, Riga 1013, Latvia

b. Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga 1006, Latvia

Crystals of two crystal modifications of droperidol: a hemihydrate (1) and the z polymorph (2), have been isolated and their structure determined using X-ray diffraction methods. Droperidol hemihydrate crystallized in the triclinic space group P - 1, with unit cell parameters a = 6.2842(15), b = 10.1473(8), c = 16.1850(2) Å; α = 102.554(9); β = 91.917(14); γ = 99.316(12)°; V = 991.6(3) Å3, and Z = 2. The droperidol z polymorph crystallized in the monoclinic space group P21/c, with unit cell parameters a = 20.0406(8), b = 7.4955(4), c = 12.9733(5) Å; β = 98.089(2)°; V = 1929.39(15) Å3, and Z = 4. In 1 and 2 two molecules of droperidol are joined by two N-H⋯O hydrogen bonds. The structure of 1 shows a possible additional hydrogen bond linking the two droperidol molecules via the water molecule.